The present study sought to compare 25(OH)D responses with 2 high-dose vitamin D2 and vitamin D3 regimens, and to observe the change in serum 25(OH)D3 levels following the supplementation of an ergocalciferol mega-dose. Therefore, less frequent administration may be a practical alternative to daily supplementation. In addition, there is a concern that vitamin D supplementation doses are frequently inadequate and that adherence with daily medication is likely to be suboptimal. Serum 25(OH)D levels following oral vitamin D supplementation permit larger dosing. 18, 19 These comparative studies used doses of both vitamins D2 and D3, ranging from 1000 to 50 000 IU. 17 – 19 Several studies comparing the 2 forms in a head-to-head manner suggest that they are equally effective in raising total serum 25(OH)D, 20 – 24 while others suggest that vitamin D2 is less effective. 8 Despite both forms being used interchangeably for vitamin D repletion, there have been conflicting data published about the equipotency of vitamins D2 and D3 there is also a concern that vitamin D2 might increase catabolism of 25(OH)D3. Vitamin D3 is manufactured by irradiating 7-dehydrocholesterol obtained from the lanolin in sheep’s wool with ultraviolet B radiation. Vitamin D2 (ergocalciferol) is manufactured from irradiation of ergosterol from yeast. 3, 14 – 16 Although humans produce vitamin D3 (cholecalciferol) endogenously, vitamin D supplements exist in 2 distinct forms. 8, 13 For the correction of vitamin D deficiency, many treatment modalities that are heterogeneous with respect to dose, dosing interval, and formulation of vitamin D supplementation are available. 3 – 12 Despite ongoing controversy, many experts agree that vitamin D deficiency is defined as circulating levels of 25-hydroxyvitamin D (25 D) less than 20 ng/mL. 1, 2 In addition, it is associated with a variety of chronic diseases such as certain cancers, cardiovascular diseases, autoimmune diseases, muscle weakness and chronic pain, diabetes (types 1 and 2), schizophrenia, and depression. Vitamin D deficiency leads to secondary hyperparathyroidism, increased bone turnover and bone loss, predisposing individuals to osteoporosis and osteoporotic fractures. The increased awareness of vitamin D deficiency and its consequences on optimal health requires an appropriate evaluation of vitamin D repletion regimens for deficient patients.
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